Pharmacokinetic Profile

EVOTAZ AND REYATAZ (atazanavir)/ritonavir DELIVERED
THE SAME EFFECTIVE DRUG LEVELS REGARDLESS OF BOOSTER1-3

Pharmacokinetic Profile: 24-Hour ATV Plasma Concentrations1-3

pharmacokinetic profile pharmacokinetic profile

ATV=atazanavir
r=ritonavir
1 μg/mL=1000 ng/mL

  • Based on the EC90: The effective drug concentration at which wild-type viral replication is inhibited by 90%4
  • Delivering a Cmin ~60x above the atazanavir EC90: Mean trough concentration through 24 hours in HIV-1 infected patients when boosted with cobicistat or ritonavir2

The clinical significance of this in vitro data is unknown

Maintaining sufficient drug concentrations can help inhibit viral replication and minimize development of resistance4,5